Allergy, Asthma
Conditions
Brief summary
Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.
Detailed description
No more description necessary.
Interventions
None listed
Sponsors
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
University of Wisconsin, Madison
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 2 Minutes
Healthy volunteers
No
Inclusion criteria
* children who had one or more parent with a history of allergy or asthma
Exclusion criteria
* pre term infants * low birth weight infants * respiratory distress at birth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the children longitudinally for the inception and progression of asthma. | Birth through age 19 | Clinical diagnosis of childhood asthma at age 6 years and older. |
Countries
United States
Outcome results
None listed