Metabolic Syndrome, Osteoporosis
Conditions
Keywords
Cholesterol, High density lipoprotein, Low density lipoprotein, Triglyceride, Glucose, Exercise, Fitness, Flax, Lignan, Phytoestrogen, bone
Brief summary
The purpose of our study is to use a flaxseed-based nutritional supplement in combination with exercise training (walking) for improving cholesterol levels. We hypothesize that exercise training will improve cholesterol profile and that adding supplementation with a flaxseed nutritional supplement will further improve cholesterol profile.
Detailed description
Flax supplementation and exercise training each have small beneficial effects for improving blood lipid profile and reducing cardiovascular disease risk. Flax lignan, a phytoestrogen found in flaxseed is thought to be the active compound responsible for the cholesterol-lowering effect of flaxseed. Our purpose is to combine an exercise training program (walking) with flax lignan supplementation for improving blood lipid profile. Comparisons: Walking (6 days per week) plus flax lignan (500 mg per day) compared to walking plus placebo.
Interventions
DIETARY_SUPPLEMENTFlax lignan
543 mg SDG per day
BEHAVIORALExercise (walking)
walking 45 minutes per day 5 days per week
Sponsors
Heart and Stroke Foundation of Canada
University of Saskatchewan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 50 years or older
Exclusion criteria
* Currently taking medication for cholesterol * Smoker * Diabetic * Gastrointestinal disease * Females on hormone replacement therapy * Currently taking a flaxseed supplement * Currently engaged in vigorous exercise training
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabolic syndrome score | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| High density lipoprotein at 2, 4, and 6 months | 6 months |
| Low density lipoprotein at 2, 4, and 6 months | 6 months |
| Triglycerides at 2, 4, and 6 months | 6 months |
| Blood glucose at 2, 4, and 6 months | 6 months |
| Body composition at 6 months | 6 months |
| Aerobic fitness at 6 months | 6 months |
| Total cholesterol at 2, 4, and 6 months | 6 months |
| Body mass index at 6 months | 6 months |
| Lumbar spine bone mineral density at 6 months | 6 months |
| Proximal femur bone mineral density at 6 months | 6 months |
| Whole body bone mineral density at 6 months | 6 months |
| Trunk fat skinfolds at 6 months | 6 months |
| inflammatory cytokines | 6 months |
| Waist Girth at 6 months | 6 months |
Countries
Canada
Outcome results
None listed