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Monitoring of Intubation and Ventilation During Resuscitation

Monitoring of Intubation and Ventilation During Resuscitation

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00204217
Enrollment
15
Registered
2005-09-20
Start date
2004-09-30
Completion date
2007-04-30
Last updated
2007-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

cardiac arrest, resuscitation, ventilation, impedance

Brief summary

Airway control and ventilation is vital during cardiopulmonary resuscitation (CPR) in cardiac arrest. Endotracheal intubation is the gold standard for airway control, but several studies have shown high rates of unrecognized placements of the tube in the esophagus instead of in the airway out-of-hospital. This is lethal. There are no failproof technique for recognising such mistakes clinically in the cardiac arrest situation. Changes on the air volume in the lungs with ventilation changes the impedance (resistance to alternating current) through the thorax. This impedance is already measured routinely by the defibrillators used during CPR. We propose that we can measure ventilation volumes and also discover failed intubations by monitoring this impedance during CPR with the possibility of giving feedback on both to the rescuers.

Detailed description

On the anesthesiologist manned ambulance in Oslo ventilation volumes during CPR will be controlled with a ventilator, the tidal volume varied in random order between 500, 700 and 100 ml, and the volumes be measured continuously as will the impedance between the defibrillator electrodes. In case of failed CPR, the patient will be declared dead. Thereafter the lungs will be ventilated with 700 ml followed by removal of the endotracheal tube, placement of an endotracheal tube in the esophagus and ventilation of this tube, again with monitoring of the impedance.

Interventions

DEVICEendotracheal intubation

Sponsors

Laerdal Medical
CollaboratorINDUSTRY
Ullevaal University Hospital
CollaboratorOTHER
Health Region East, Norway
CollaboratorOTHER
Norwegian Air Ambulance Foundation
CollaboratorOTHER
University of Stavanger
CollaboratorOTHER
University of Oslo
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Cardiac arrest

Exclusion criteria

* \<18 years old trauma pregnancy

Design outcomes

Primary

MeasureTime frame
sensitivity/specificity for lung ventilation detection
correlation ventilation volume - impedance change

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026