ARDS
Conditions
Keywords
ARDS, mechanical ventilation, variable ventilation, chaotic ventilation
Brief summary
The purpose of this study is to determine the effects of variable ventilation on respiratory system of patients affected by acute respiratory distress syndrome.
Detailed description
In this interventional study we want to evaluate the effect of Variable ventilation (1) in patients with ARDS. Patients will be mechanically ventilated with Variable Ventilation (3 step with increased level of variability) and traditional CMV, for a total of 4 step. Each step lasts in 60 minutes. During this period we will record the gas exchange parameters and the mechanics of the respiratory system. 1\. Arold S, Mora R, Lutchen K, et al. Variable ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury. Am J Resp Crit Care Med 2000; 165: 366-71.
Interventions
PROCEDUREVariable ventilation
Patients will be mechanically ventilated with Variable Ventilation (3 step with increased level of variability) and traditional CMV, for a total of 4 step. Each step lasts in 60 minutes. During this period the investigators will record the gas exchange parameters and the mechanics of the respiratory system.
Sponsors
Policlinico Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with ARDS criteria
Exclusion criteria
* Age less than 18 years * Severe haemodynamic instability * Patients with clinical or instrumental evidence of flow-limitation (i.e., PEEPi)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gas exchange and respiratory mechanics | within the first 60 minutes from the ventilatory change |
Countries
Italy
Outcome results
None listed