Choline Quantification in Breast Cancer by MRS

Breast Neoplasms

Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline concentration. The purpose of this study is to establish methods for quantification of choline in breast cancer by MRS

1. Establishment of new MRS sequence for choline quantification of choline. This sequence is choline-selective, and signals from water and lipids are suppressed simultaneously. 2. Compare to different methods for choline quantification. The first method is quantification through an external phantom standard, containing a known concentration of choline. The other method is based on the utilisation of internal water signal as a reference. Both calculations can be performed from the same MR exam. Ten patients will be included in the study.

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