Urinary Tract Infection
Conditions
Keywords
Urinary tract infection, Vesico-renal reflux, Child, Antimicrobial prophylaxis, Recurrence of urinary tract infection
Brief summary
Randomized, prospective, multicenter study in order to assess the usefulness of antimicrobial prophylaxis in children with isolated vesico-ureteral reflux (grade III or less).
Detailed description
A voiding cystourethrogram was performed for each child less than 3 years old with a first urinary tract infection. In case of vesico-ureteral reflux, a randomization was done between continuous antimicrobial prophylaxis with low dose of trimethoprim-sulfamethoxazole and no antibioprophylaxis. Duration of follow up was 18 months.
Interventions
PROCEDUREAntimicrobial prophylaxis
Sponsors
Nantes University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 3 Years
Healthy volunteers
No
Inclusion criteria
* Children less than 3 years old * First proved urinary tract infectionIsolated vesico-ureteral reflux * Parents have been fully informed and have given written informed consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| End point : recurrence of urinary tract infection during the study period (0 è 18 months) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Type of urinary tract infection (pyelonephritis or cystitis) | — |
| 2) Evaluation of the quality of life with a validated questionnaire done at 9 months | — |
Countries
France
Outcome results
None listed