Third Stage of Labour
Conditions
Keywords
oxytocin, third stage, dose, route, blood loss
Brief summary
Mothers are given the medication oxytocin after birth to help the uterus (womb) contract and therefore reduce blood loss. In Canada, oxytocin is given either into the muscle of the thigh or into a vein. However, it is not known which route is better.This study will test which dose and route of oxytocin is best in reducing blood loss following vaginal delivery.
Interventions
DRUGoxytocin
Sponsors
Memorial University of Newfoundland
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* women 19 years and older * singleton pregnancy * 32 weeks gestation * spontaneous vaginal delivery
Exclusion criteria
* previous postpartum hemorrhage * placenta previa * grand multiparity (\>4) * anticoagulation therapy * delivery prior to 32 weeks gestation * operative vaginal delivery * antepartum hemorrhage \> 20 weeks * hemoglobin \<10g/dL * multiple gestation * intrauterine death
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in hematocrit | — |
Secondary
| Measure | Time frame |
|---|---|
| postpartum hemorrhage (estimated blood loss > 500cc) | — |
| severe postpartum hemorrhage (estimated blood loss > 1000cc) | — |
| incidence of hypotension | — |
| length of third stage of labour | — |
| need for blood transfusion | — |
| incidence of retained placenta | — |
| estimated blood loss | — |
| need for hysterectomy | — |
| need for additional oxytocics after delivery | — |
| postpartum antibiotic use | — |
| maternal satisfaction | — |
| bleeding needing readmission | — |
| need for dilatation and curettage | — |
Countries
Canada
Outcome results
None listed