Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00197886

Enrollment

Registered

2005-09-20

Start date

2004-10-31

Completion date

2005-12-31

Last updated

2006-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Brief summary

Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid. This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.

Interventions

DRUGChanging dose of norepinephrine and blood pressure

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Septic shock * NE-dose \> 0.1 microg/kg/min * CI \> 3.0 l/min/m2

Exclusion criteria

* Age \< 18, unable to obtain informed consent from relatives * Untreated hypertension * Pregnancy * Pathology in the rectum or stomach * Limitation of therapy

Design outcomes

Primary

Measure	Time frame
L-lactate concentration in the rectum and stomach.	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026