HIV Infections
Conditions
Keywords
Prevention of Mother-Infant HIV Transmission
Brief summary
The goals of this study are to: 1. determine the diarrheal rates, morbidity, mortality, and pathogens present among breast-fed infants born to HIV-infected mothers. * analysis by HIV status of infants, method of feeding, HIV viral loads / CD4 counts of infected mothers. * comparison to rates among infants born to HIV uninfected mothers. 2. link analysis of the functional quality of immunoglobulins in the breast milk of HIV-infected and uninfected mothers.
Interventions
None listed
Sponsors
Botswana Ministry of Health
Harvard School of Public Health (HSPH)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Subject is able to provide independent informed consent. * Subject is able to complete a questionnaire as part of her enrollment visit and agrees to complete follow-up questionnaires monthly. * Subject presents symptoms of acute diarrhea: at least 3 loose stools during 24 hours as reported by mother; persistent diarrhea: an episode of diarrhea lasting 14 days; recurrent diarrhea: a new episode of diarrhea after an interval of at least two diarrhea-free days. For HIV-infected subjects: * Mother: HIV antibody is detected by dual HIV-1 ELISA and confirmed by western blot. Infant: HIV antigen is detected by PCR on 2 samples during the follow-up period, or on 1 sample followed by the death of the infant.
Exclusion criteria
* Subject cannot provide legal independent informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OCCURRENCE OF SUSPECTED PNEUMONIA OR BLOODSTREAM INFECTION OVER FIRST TWO YEARS OF LIFE | 24 months |
Countries
Botswana
Outcome results
None listed