Major Depression
Conditions
Brief summary
This study will determine the effectiveness of offering primary care patients their preferred treatment versus one that is less desirable in improving treatment adherence and outcome.
Detailed description
This study investigates whether offering primary care patients treatment that is congruent with their preferred first choice improves adherence and outcomes, in comparison to offering treatment that is not congruent with their preferred first choice. All subjects are offered a treatment with demonstrated efficacy, namely either the antidepressant medication escitalopram or Interpersonal Psychotherapy for 5 months. We hypothesize that patients who receive congruent treatment will be more likely to initiate treatment, adhere to treatment, and achieve depression remission.
Interventions
DRUGescitalopram
BEHAVIORALinterpersonal psychotherapy
Sponsors
National Institute of Mental Health (NIMH)
Weill Medical College of Cornell University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age 21-99 * English-speaking * DSM-IV criteria for major depression
Exclusion criteria
* unable to give informed consent * MMSE\<24 * DSM-IV diagnosis of bipolar disorder, psychotic disorder, current alcohol or substance abuse * active suicide ideation * aphasia * acute or severe medical illness * currently receiving either antidepressant medication or psychotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| treatment initiation | — |
| treatment adherence | — |
Secondary
| Measure | Time frame |
|---|---|
| depressive symptomatology | — |
Countries
United States
Outcome results
None listed