Factor V Leiden Mutation and Implantation Failure

Evaluation of the Role of Factor V Leiden Mutation in Implantation Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00194350

Enrollment

399

Registered

2005-09-19

Start date

2001-09-30

Completion date

2005-08-31

Last updated

2011-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Infertility, Factor V Leiden

Brief summary

The purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in IVF. The specific condition to be studied is the presence or absence of the Leiden mutation of the Factor V gene.

Interventions

PROCEDURETest for Factor V Leiden gene mutation

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization * Transfer of at least 2 fresh embryos of Grade 2 (preembryo with blastomeres of equal size and \<=10% cytoplasmic fragmentation) or better

Exclusion criteria

* Infertility due to uterine anatomic defect * Current use of anticoagulant medication, such as heparin or aspirin * Known presence of any other condition associated with increased risk of thrombosis

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026