Infertility Markers in Serum, Urine, and Follicular Fluid

Markers in Women Undergoing Infertility Treatment

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00194220

Enrollment

1235

Registered

2005-09-19

Start date

2002-09-30

Completion date

2013-02-28

Last updated

2015-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

Infertility, Oxidative stress

Brief summary

This study is only collecting specimens from current patients of PENN Fertility Care. The purpose of this investigation is to assess if markers of oxidative stress that are known to be associated with other medical conditions can be detected in women undergoing infertility treatment and normal women of similar age. Oxidative stress may affect a woman's eggs or the follicular cells that surround and nurture them. Other markers of to be investigated include markers of cellular aging and DNA structural changes. Presence of these markers will be compared in blood and urine samples taken during infertility treatment, and follicular fluid at the time of IVF (if applicable).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Women aged 18-50 * Infertility patients only: 1. Women undergoing infertility treatment (with or without in-vitro fertilization) at the University of Pennsylvania's PENN Fertility Care 2. Verified infertility diagnosis of any of the following: * Endometriosis (minimal or mild) * Endometriosis (moderate or severe) * Tubal factor * Hypogonadotrophic hypogonadism * Polycystic ovary syndrome * Diminished ovarian reserve * Male factor * Unexplained * Healthy normal volunteers only: 1. Not undergoing infertility treatment 2. Not using hormonal contraception

Exclusion criteria

* Currently pregnant or breastfeeding * Post-menopausal * Concurrent participation in investigational trial * Other health problems which, in the opinion of the investigator, may affect participation

Countries

United States

Outcome results