Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

A Double-blind, Placebo-controlled, Crossover Pilot Study of the Efficacy of Celecoxib 200 mg qd in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00194090

Enrollment

Registered

2005-09-19

Start date

2004-06-30

Completion date

2005-09-01

Last updated

2022-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

pain, osteoarthritis

Brief summary

A paced 20-minute walk is a reproducible model for acute pain in knee osteoarthritis

Detailed description

This is a randomizd, placbo-controlled, crossover trial comparing a single dose of celecoxib to placebo measuring the time to onset of acute pain in a paced 20-minute walk. 40 subjects will be enrolled

Interventions

DRUGcelecoxib

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

45 Years to 85 Years

Healthy volunteers

Inclusion criteria

Knee osteoarthritis by ACR clinical criteria Pain of at least 40 mm by VAS at baseline \-

Exclusion criteria

Non-pregant, non-lactating Able to stop active arthritis medication for washout Cardiovascular risk factors Abnormal EKG -

Design outcomes

Primary

Measure	Time frame
time to onset of severe pain	—

Secondary

Measure	Time frame
time to onset of moderate pain	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026