The CRT-KIR Study (Cardiac Resynchronization Therapy [CRT] in the Early Phase After Heart Surgery)

Cardiac Resynchronization Therapy (CRT) in the Early Phase After Heart Surgery

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00192946

Enrollment

Registered

2005-09-19

Start date

Unknown

Completion date

2008-09-30

Last updated

2007-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bundle-Branch Block

Keywords

Cardiac resynchronization, Heart failure, open heart surgery, surgery

Brief summary

In patients with broad QRS complexes on electrocardiogram (ECG), the delayed electrical activation of the left heart chamber will cause abnormal contraction.This has been shown to be possible to treat by a special pacemaker treatment which includes pacing of the left heart chamber (= CRT treatment). In this study the researchers will investigate the effect of acute CRT treatment in the early phase after open heart surgery.

Detailed description

Patients with bundle branch block have a delayed electrical activation of the left ventricle causing abnormal contractility of the left ventricle. We hypothesize that patients may benefit from short term (= 72 hours) CRT (Cardiac Resynchronization Therapy) in the early phase after open heart surgery. Patients: reduced LV function and bundle branch block. Study type: randomisation to CRT versus standard postoperative treatment Study variables: cardiac output, echocardiographic measures, p-BNP and hours with inotropic therapy.

Interventions

PROCEDURETemporary cardiac resynchronization therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient scheduled for open heart surgery (coronary artery bypass graft \[CABG\] or mitral valve surgery or aortic valve surgery or combinations of the above mentioned surgical procedures) and LV ejection fraction \< 35% and bundle branch block (QRS \> 9.12 s)

Exclusion criteria

* Severe right heart failure * Permanent atrial fibrillation * Congenital heart disease * Serious non-cardiac disease

Design outcomes

Primary

Measure	Time frame
Non invasive cardiac output after 72 hours CRT (versus control) treatment	—

Secondary

Measure	Time frame
Echocardiographic measures of left ventricular (LV) function	—
Mixed venous oxygen saturation	—
Invasively determined cardiac output	—
Plasma brain natriuretic peptide (p-BNP)	—
Number of hours with inotropic treatment	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026