Bacterial Infections, Malaria, Pyelonephritis
Conditions
Keywords
FUNCTIONAL STUDY, CONTRAST-ENHANCED US, PERFUSION
Brief summary
To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as acute pyelonephritis at day 0 (within 8 hours of the treatment start), day 2 to 4 and day 28-32, using functional US with continuous infusion of a contrast agent (SonoVue, Bracco, Italy). Study hypothesis: malaria patients should exhibit a different pattern of enhancement, particularly when quantitative measurements of the SU signals is performed with destruction reperfusion kinetics.
Detailed description
To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as acute pyelonephritis at day 0 (within 8 hours of the treatment start), day 2 to 4 and day 28-32, using functional US with continuous infusion of a contrast agent (SonoVue, Bracco, Italy). Three cohortes will be studied: cohorte 1 infection at Plasmodium falciparum (24 patients), cohorte 3 infection at Plasmodium vivax, ovale or malariae (5 patients) and cohorte 2 other infectious diseases such as acute pyelonephritis (24 patients). Study hypothesis: malaria patients should exhibit a different pattern of enhancement, particularly when quantitative measurements of the SU signals is performed with destruction reperfusion kinetics.
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
DEFINED_POPULATION
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Social security number * Age over 18 * acute malaria infection or other infectious diseases * Inpatients * Signed informed consent form
Exclusion criteria
* Pregnancy * Criteria of bad tolerance of infection * Treatment started for more than 8 hours * Lack of cooperation * History of splenectomy, hematological disease, cirrhosis with portal hypertension, splenomegaly * Medical treatment with beta blocker, diuretic, immunodepression drugs
Countries
France
Contacts
Primary ContactOlivier Lortholary, MD PhD
Outcome results
None listed