Chronic Respiratory Failure
Conditions
Brief summary
Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode. The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.
Detailed description
The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.
Interventions
PROCEDURErespiratory settings
Sponsors
Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Chronic respiratory failure * Clinical symptoms of chronic alveolar hypoventilation * PaCO2 ≥ 45 mmHg in case of restrictive pulmonary disorder or PaCO2 ≥ 55 mmHg in case or obstructive pulmonary disorder
Exclusion criteria
* Clinical exacerbation during the three previous weeks * Previous treatment by domiciliary non invasive ventilation * Previous treatment by non invasive ventilation for acute respiratory failure during the 3 previous months * Bronchiectasis * Duchenne muscular dystrophy * Amyotrophic lateral sclerosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PaO2 | months | Blood gases response to ventilation |
Outcome results
None listed