Left Ventricular Dysfunction
Conditions
Keywords
Myocardial Protection, Myocardial Metabolism, Ventricular Function, Cardiovascular Disease, Cardioplegic Additives
Brief summary
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular function (e.g. ejection fraction \<40%).
Detailed description
Hypothesis Insulin added to blood cardioplegia will improve the results of Coronary Artery Bypass Graft by reducing the incidence of low output syndrome (i.e., the requirement for inotropic or balloon pump assistance) in patients with a preoperative ejection fraction \<40%.
Interventions
DRUGInsulin Cardioplegia
Sponsors
Canadian Institutes of Health Research (CIHR)
University Health Network, Toronto
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
0 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient has been referred for isolated coronary bypass surgery. * LV grade 3 or 4, LVEF \<40% by angio, echo, RNA.
Exclusion criteria
* Patient is undergoing reoperative surgery (i.e., has had any previous cardiac surgery) * Surgeon has planned another procedure in addition to coronary bypass surgery (e.g., valve repair, replacement, ascending aorta repair or replacement, left ventricular aneurysm resection, repair of congenital defect, carotid surgery, repair of abdominal aortic aneurysm). * Patient is scheduled for minimally invasive surgery. * More recent assessment of LV function with LV grade 1 0r 2, LVEF\>40%. * 5 or 6 days post MI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low Output Syndrome | — |
Secondary
| Measure | Time frame |
|---|---|
| Total Troponin I Release | — |
Countries
Canada
Contacts
Primary ContactChet Jabier-Nacario, BScN
Outcome results
None listed