Diastolic Dysfunction and Atrial Fibrillation in CABG Surgery

Diastolic Dysfunction and Atrial Fibrillation in Patients Undergoing Coronary Revascularization Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00188903

Enrollment

250

Registered

2005-09-16

Start date

2004-03-31

Completion date

2010-03-31

Last updated

2010-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Heart Disease

Keywords

Cardiac Surgery, Diastolic Dysfunction, Atrial Fibrillation

Brief summary

Left ventricular (LV) diastolic dysfunction is a common manifestation of heart disease that is responsible for significant morbidity and mortality.It is present when the ventricular filling is impaired as a result of delayed relaxation or decreased compliance. During Coronary artery bypass grafting (CABG) surgery, LV diastolic dysfunction is a frequent occurrence. Failure of the left ventricle to dilate normally causes an increase in LV filling pressure. Atrial fibrillation (AF) is a common complication after cardiac surgery affecting 20-30% of patients undergoing coronary revascularization procedures. AF is associated with significant morbidity and mortality and has been identified as a causative factor of increased length of both hospital and intensive care unit (ICU) stay after CABG surgery, resulting in increased resource utilization and medical care costs.The primary aim of this study is to determine if patients with preoperative diastolic dysfunction are exposed to higher risk of AF after coronary revascularization surgery.

Interventions

PROCEDUREDiastolic measurements during TEE

Transesophageal echocardiography with diastolic measurements

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* scheduled for elective CABG or OPCAB surgery * signed informed consent

Exclusion criteria

* Patients with a history of previous heart surgery and/or undergoing valvular heart surgery. * Patients with preoperative atrial fibrillation. * Patients in whom TEE is contraindicated.

Design outcomes

Primary

Measure	Time frame
Is to determine if patients with preoperative diastolic dysfunction are exposed to higher risk of AF after coronary revascularization surgery.	pre and post operative

Secondary

Measure	Time frame
Is to determine if diastolic dysfunction and AF are associated with increased perioperative cardiac morbidity and reduced event-free survival.	post operative until discharge

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 20, 2026