IMRT Lower Limb Soft Tissue Sarcoma

A Phase II Study of Preoperative Intensity-Modulated Radiation Therapy For Lower Limb Soft Tissue Sarcoma

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00188175

Enrollment

Registered

2005-09-16

Start date

2003-05-31

Completion date

2013-05-31

Last updated

2014-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcoma

Brief summary

Intensity-modulated radiation therapy may make wound healing problems less likely by 1)precisely shaping the region of high radiation dose to the shape of the tissue which harbours tumour cells, and 2) precisely shaping the regions of low radiation dose to the shapes of the normal tissues which are more sensitive to radiation effects.

Interventions

RADIATIONIntensity Modulated Radiation Therapy

Pre-op Intensity Modulated Radiation Therapy for lower limb soft tissue sarcoma.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

* Histologically proven soft tissue sarcoma * Lesion lies between the iliac crest (hipbone) and the ankle * Lesion is newly diagnosed * Assessed by radiation oncologist and surgical oncologist

Exclusion criteria

* Benign histologies * Histologies generally treated with chemotherapy * Prior or recurrent cancer, except nonmelanomatous skin cancer or carcinoma in-situ of the cervix

Design outcomes

Primary

Measure	Time frame
Major wound complications within 120 days following surgery	120 days post-op

Secondary

Measure	Time frame
Assess acute and late radiation toxicity including limb edema	up to120 days

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026