Focus Groups
Conditions
Keywords
Healthy Cohort
Brief summary
Collect DNA from well-characterized healthy volunteers.
Detailed description
DNA and plasma will be used to identify and determine allele frequencies of genetic variants in membrane transporters and other genes relevant to human disease or drug response, including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease, asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve as the hypothesis-generating phase for future studies by identifying genetic variants and determining allele frequencies among an ethnically diverse cohort of healthy volunteers. Future investigations (separate IRB applications) will attempt to correlate genotypes to phenotypes among this cohort of volunteers. The allele identification and frequency data from this group of healthy volunteers will also be used to design association studies in relevant disease populations. Determine if identified sequence variants are associated with gain or loss of in vitro biologic function using lymphocytes obtained from patients.
Interventions
None listed
Sponsors
University of California, San Francisco
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adult subjects of both genders and specified ethnic groups * Subjects must be between 18-40 years of age
Exclusion criteria
* Smokers * Drink \> 2 alcoholic beverages/day * Take any chronic medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Healthy Control | On-going | Amass a cohort of healthy controls to be used for future genotype to phenotype studies. |
Countries
United States
Outcome results
None listed