Natural History of Hepatitis C in Patients With Normal Liver Tests

Determinants of Disease Severity in Patients With Chronic Hepatitis C and Normal Serum Aminotransferases (Normal Liver Tests)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00187473

Enrollment

Registered

2005-09-16

Start date

2000-06-30

Completion date

2021-12-31

Last updated

2024-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Hepatitis C

Keywords

hepatitis C, HCV, natural history

Brief summary

The Major goals of this project was to assess the natural history of disease in chronic hepatitis C patients with normal ALT and to determine the virologic and host factors associated with disease severity.

Interventions

PROCEDUREliver biopsy

Liver biopsy every 5 years

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with chronic hepatitis C and persistently normal liver enzymes * able to give consent

Exclusion criteria

* decompensated liver disease * any prior antiviral or immunosuppressive therapy * other liver disease besides hepatitis C

Design outcomes

Primary

Measure	Time frame
ALT	March 2015

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026