Unipolar Depression
Conditions
Keywords
Repetitive Transcranial Magnetic Stimulation, TMS
Brief summary
Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression. In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.
Detailed description
Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.
Interventions
PROCEDURETranscranial Magnetic Stimulation (TMS)
treatment for 10 days
Sponsors
Queen's University, Kingston, Ontario
St. Joseph's Healthcare Hamilton
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Major Depression * No physical health problems
Exclusion criteria
* History of Epilepsy * Metal in the head/neck or skull * Pacemaker * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale | Pre TMS and post TMS |
| Beck Depression Rating Scale | pre TMS and post TMS |
Secondary
| Measure | Time frame |
|---|---|
| Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow | pre TMS and post TMS as well as post phase II, second set of TMS |
Countries
Canada
Outcome results
None listed