Skin Diseases
Conditions
Brief summary
This study aims to establish a novel approach assisting the rational development of analgesic and anti-inflammatory drugs. In a first step we will test in healthy human volunteers whether proteins mediating inflammation and pain can be detected in an experimentally induced inflammatory skin lesion. Fluids that will be used to detect such proteins will be collected from the inflamed skin site via small porous catheters. We wish to establish the expression pattern of different proteins and correlate it with various tests assessing pain.
Interventions
PROCEDUREMicro-plasmapheresis
Sponsors
Martin Angst
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age between 21-60. 2. Skin type II or III according to the classification of Fitzpatrick (II: fair skin, always burns, sometimes tans, III: medium skin, sometimes burns, always tans).
Exclusion criteria
1. History of a significant systemic disease, a dermatological disease, bleeding disorder, or chronic pain. 2\. Consumption of analgesic drugs. 3. Hypersensitivity to sunlight.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine-release profile in response to inflammation, noxious heat, and asministration of a COX-inhibitor | — |
Countries
United States
Outcome results
None listed