Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

Stem Cell Transplantation From Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00186225

Enrollment

250

Registered

2005-09-16

Start date

1989-11-30

Completion date

2010-05-31

Last updated

2020-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood and Marrow Transplant (BMT), Blood Cancer

Brief summary

To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

Detailed description

Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.

Interventions

PROCEDUREablative allogeneic hematopoietic cell transplantation

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

4 Weeks to 50 Years

Healthy volunteers

Inclusion criteria

- acute leukemia * chronic leukemia * lymphoblastic lymphoma * MDS * MPS

Exclusion criteria

- organ dysfunction * HIV positive

Design outcomes

Primary

Measure	Time frame
oxicity and efficacy of TBI and cyclophosphamide as preparation for hematopoietic cell transplantation from partially matched and unrelated donors.	—

Secondary

Measure	Time frame
Overall Survival	—
Event Free Survival	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026