The Relative Effects of Olmesartan Medoxomil, Irbesartan and Valsartan on the Activity of the Blood Pressure Control System in Healthy Subjects

The Relative Effects of Single Doses of Olmesartan Medoxomil, Irbesartan and Valsartan at High Dosage Levels on the Renin-Angiotensin-Aldosterone System in Healthy Normal Subjects

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00185055

Enrollment

Registered

2005-09-16

Start date

2004-11-30

Completion date

2005-02-28

Last updated

2005-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

olmesartan, valsartan, irbesartan, renin-angiotensin-aldosterone system

Brief summary

To assess the effects of 3 blood pressure drugs, called angiotensin receptor blockers, on the blood pressure control systems in healthy subjects.

Interventions

DRUGOlmesartan medoxomil

DRUGIrbesartan

DRUGValsartan

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Men and women between the ages of 18 to 65 * In good health

Exclusion criteria

* Any serious health problems * Positive test for HIV, Hepatitis B and C * History of drug and alcohol abuse

Design outcomes

Primary

Measure	Time frame
To characterize the plasma renin activity (PRA) and urinary aldosterone response patterns to single doses of olmesartan medoxomil, irbesartan, and valsartan compared to placebo in normal volunteers.	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026