Endotoxemia
Conditions
Keywords
Endotoxemia, vascular potassium channels, cytokine, norepinephrine, regional blood flow,, inflammation,, ion channels,, nitric oxide synthase,, pharmacology.
Brief summary
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
Interventions
Sponsors
ZonMw: The Netherlands Organisation for Health Research and Development
Radboud University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers
Exclusion criteria
* drug, alcohol, nicotine abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamics | 24 hrs after LPS administration |
| Markers of Inflammation | 24 hrs after LPS administration |
| Cytokines | 24 hrs after LPS administration |
| Markers of Renal Injury | 24 hrs after LPS administration |
| Inducible NO synthase expression | 24 hrs after LPS administration |
| NO-metabolites | 24 hrs after LPS administration |
| Mediators of Vascular reactivity | 24 hrs after LPS administration |
| Sensitivity to norepinephrine | 24 hrs after LPS administration |
Outcome results
None listed