The Effect of Caffeine on Ischemic Preconditioning

Caffeine Reduces Acute Ischemic Preconditioning

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00184912

Enrollment

Registered

2005-09-16

Start date

2003-09-30

Completion date

2006-01-31

Last updated

2006-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caffeine, Ischemic Preconditioning, Ischemia-Reperfusion Injury

Brief summary

Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor antagonist already at concentrations reached after regular coffee consumption, we aimed to assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle. 24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes) or saline before a protocol for IP.

Interventions

DRUGcaffeine

DRUGTechnetium-TC99m-labeled Annexin A5

PROCEDUREten minutes forearm ischemia

PROCEDUREischemic forearm exercise

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy male volunteers

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Percentual difference in Annexin A5 targetting between the experimental and control arm one and four hours after intravenous injection.	—

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026