The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00184899

Enrollment

Registered

2005-09-16

Start date

2005-08-31

Completion date

2006-08-31

Last updated

2007-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Syndrome X, Obesity

Keywords

free fatty acids, vasodilation, sympathetic activity

Brief summary

The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation. The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.

Interventions

DRUGIntravenous infusion of Intralipid/heparin

DRUGIntravenous infusion of Glycerol/heparin

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

ECT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers

Exclusion criteria

* Pregnancy * Asthma * Use of medication * Cardiovascular/pulmonary disease and diabetes

Design outcomes

Primary

Measure	Time frame
Forearm blood flow	—
Vasoactive effect of caffeine	—
Sympathetic activity (noradrenaline spillover, spectral analysis)	—

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026