Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00184444

Enrollment

Registered

2005-09-16

Start date

2004-09-30

Completion date

2007-07-31

Last updated

2016-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina Pectoris

Keywords

angina pectoris, hyperoxia, endurance training, stroke volume, cardiac perfusion

Brief summary

The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured. The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.

Interventions

BEHAVIORALHypoxic interval training

4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max

BEHAVIORALNormoxic interval training

4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* stable angina pectoris age 18-75

Exclusion criteria

* unstable angina pectoris * Limitations to exercise other than coronary artery disease * Participants in other study interventions

Design outcomes

Primary

Measure	Time frame
maximal oxygen uptake	Baseline and post training

Secondary

Measure	Time frame
Cardiac perfusion	Baseline and post training
work economy	Baseline and post training
cardiac output	baseline and post training

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026