Post-Traumatic Stress Disorder
Conditions
Keywords
Post-traumatic stress disorder, PTSD, Prolonged Exposure, Cognitive-Behavior Therapy
Brief summary
This study will determine the effectiveness of immediate treatment with prolonged exposure therapy (PE) versus delaying treatment with PE in altering neuroendocrine-related symptoms of post-traumatic stress disorder in women.
Detailed description
Post-Traumatic Stress Disorder (PTSD) is a psychiatric disorder that can occur following exposure to a traumatic incident in which grave physical harm occurred or was threatened. PTSD is marked by clear biological changes as well as psychological symptoms. Many people with PTSD repeatedly relive the trauma in the form of flashback episodes, memories, nightmares, or frightening thoughts. Chronic PTSD can also affect the neuroendocrine system by altering functionality of some chemicals in the brain, including cortisol and catecholamines (e.g., norepinephrine). This study will determine the effectiveness of immediate treatment with prolonged exposure therapy (PE) versus delaying treatment with PE in altering neuroendocrine-related symptoms of post-traumatic stress disorder in women. This single-blind study will randomly assign two thirds of participants to PE therapy immediately following a traumatic event and one third to a waitlist condition (WL), in which they will receive no treatment until a later date. Participants assigned to receive PE will do so once weekly for 10 weeks. Participants assigned to the WL condition will receive no treatment for 10 weeks, and then will begin PE therapy once weekly for an additional 10 weeks. Study visits will occur at baseline, Week 10, and 6 months post-treatment for those in both conditions, with additional visits 10 weeks and 6 months post-PE therapy for those in the WL condition. Psychological measurements to be assessed at these visits will include PTSD symptoms, anxiety, depression, and PTSD-related cognitions. Physical assessments will include urine and saliva tests, as well as a dexamethasone-suppression test. Participants in the PE condition will also provide saliva samples at points throughout the study to monitor changes in cortisol and catecholamines.
Interventions
BEHAVIORALProlonged Exposure Therapy
Sponsors
National Institute of Mental Health (NIMH)
University of Pennsylvania
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Chronic post-traumatic stress disorder * Minimum of 3 months passed since traumatic event happened * Agree to use an effective form of contraception throughout the study
Exclusion criteria
* History of schizophrenia, bipolar disorder, or cognitive dysfunction due to a general medical condition * History of alcohol or other drug abuse or dependence within 3 months of study enrollment * Mental retardation or other pervasive developmental disorder * Unwillingness or inability to discontinue current psychotherapy treatment (stable psychiatric medication therapy taken during the study is not criteria for exclusion) * Significant risk of violence or history of serious violent behavior within one year of study enrollment * Medically unstable condition * Continuing intimate relationship with the perpetrator when the trauma involves assault * At risk for suicide risk * Currently pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PTSD severity; measured by the PSS-I immediately after 10 weeks of treatment and at 6-month follow-up | — |
| Salivary cortisol; measured immediately after 10 weeks of treatment | — |
| Urinary cortisol and catecholamines; measured immediately after 10 weeks of treatment and at 6-month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression; measured by the BDI immediately after 10 weeks of treatment and at 6-month follow-up | — |
| Salivary cortisol; measured at 6-month follow-up | — |
| State-anxiety; measured by the STAI-S immediately after 10 weeks of treatment and at 6-month follow-up. | — |
| Trauma-related cognitions; measured by the PTCI immediately after 10 weeks of treatment and at 6-month follow-up | — |
Countries
United States
Outcome results
None listed