D-Dimer Vs Serial Compression Ultrasound Study

Evaluation of the Safety, Efficacy and Cost-Effectiveness of Two Strategies for the Diagnosis of Deep Vein Thrombosis

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00182351

Enrollment

810

Registered

2005-09-16

Start date

1996-04-30

Completion date

1999-07-31

Last updated

2006-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Vein Thrombosis

Keywords

deep vein thrombosis, d-dimer, serial compression ultrasound

Brief summary

To determine whether d-dimer testing can be used to simplify and reduce the costs of the diagnostic approach to patients with clinically suspected deep vein thrombosis

Interventions

PROCEDURED-dimer

PROCEDURESerial Compression Ultrasound

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

0 Years to No maximum

Healthy volunteers

Inclusion criteria

* first suspected deep vein thrombosis * no previous venous thromboembolism * referred to thromboembolism outpatient clinic

Exclusion criteria

* comorbid condition limiting survival to less than six months * contraindication to venography (contrast allergy, etc.) * receiving long term warfarin therapy * receiving full dose heparin therapy for more than 48 hours * absence of symptoms during the five days immediately prior to presentation * symptoms of pulmonary embolism * pregnancy * geographic inaccessibility which precludes follow-up

Design outcomes

Primary

Measure	Time frame
safety of withholding anticoagulants	—

Secondary

Measure	Time frame
deep vein thrombosis	—
pulmonary embolism	—
death	—

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026