Deep Vein Thrombosis, Pulmonary Embolism
Conditions
Keywords
deep vein thrombosis, DVT, pulmonary embolism, PE, venous thromboembolism, VTE, d-dimer, IPG
Brief summary
To simplify and improve the diagnostic approach to patients with clinically suspected recurrent DVT by determining whether the results of the combination of IPG and d-dimer testing, using a whole blood agglutination assay, can be used in the management of such patients.
Interventions
PROCEDUREvenogram
Sponsors
Heart and Stroke Foundation of Canada
Hamilton Health Sciences Corporation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* suspected deep vein thrombosis * history of previous DVT or PE
Exclusion criteria
* comorbid condition limiting survival to less than 6 months * contraindication to contrast medium (allergy, renal dysfunction, creatinine \> 150mcmol/L) * receiving long-term warfarin or heparin therapy * received full-dose heparin therapy for more than 48 hours * pregnancy * symptomatic for pulmonary embolism * absence of symptoms within 5 days of presentation * geographic inaccessibility which precludes follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| symptomatic DVT and PE in follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| death | — |
| deep vein thrombosis diagnosed by venography in those | — |
| randomized to that intervention | — |
Countries
Canada, Italy
Outcome results
None listed