Pharmacokinetics of Curcumin in Healthy Volunteers

Evaluation of Naturally Occurring Inhibitors of UDP-glucuronyltransferase on the Oral Bioavailability of Curcumin in Normal Healthy Volunteers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00181662

Enrollment

Registered

2005-09-16

Start date

2005-08-31

Completion date

2007-10-17

Last updated

2020-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Curcumin, Piperine, Silybin, Healthy volunteer, Female

Brief summary

This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.

Detailed description

Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.

Interventions

DRUGCurcumin

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteer * On no medications except for birth control pills * Signed informed consent

Exclusion criteria

* Pregnant * Comorbid disease

Design outcomes

Primary

Measure	Time frame
Curcumin pharmacology	—

Secondary

Measure	Time frame
Interactions between piperine and curcumin	—
Interactions between silybin and curcumin	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026