Chronic Obstructive Pulmonary Disease
Conditions
Brief summary
Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.
Detailed description
As in Brief description
Interventions
Sponsors
GlaxoSmithKline
Imperial College London
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* FEV1 \< 70% predicted at baseline on spirometry * significant smoking history or alpha 1 antitrypsin deficiency * no evidence of current infection or restrictive lung disease
Exclusion criteria
* history of other significant respiratory disease * significant respiratory infection within 6 weeks * history of significant physical or mental illness rendering them unfit for the study in the opinion of the investigator * taken part in any other research within the past 12 months, or received exposure to ionizing radiation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| scan grade | post scan | previously validated grading score |
Secondary
| Measure | Time frame |
|---|---|
| lung function | pre scan |
Countries
United Kingdom
Outcome results
None listed