Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

Combination of Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00180804

Enrollment

400

Registered

2005-09-16

Start date

2005-04-30

Completion date

2005-08-31

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent Miscarriages

Brief summary

For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.

Detailed description

Little is known about reasons for early pregnancy failures. It is believed that some pathology leading to defective implantation of fetus in maternal uterus may lead to recurrent early miscarriages. This project arises from previous work on pre-eclampsia where we found combination of maternal immune genes (KIR) with their ligand (HLA-C) in the fetus was strongly associated with the disease. We will tissue type the fetus, mother and father in cases of unexplained miscarriages. We hope that genetic findings in recurrent miscarriage will lead to new insights, prevention and treatment.

Interventions

None listed

Study design

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

Couples with 3 or more unexplained miscarriages

Exclusion criteria

Previous livebirths, parental karyotypic abnormalities, thrombophilic defects, uterine structural abnormalities

Countries

United Kingdom

Outcome results