Brain Tumors, Medulloblastoma, Neuroectodermal Tumors, Primitive
Conditions
Keywords
Brain PNET
Brief summary
The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.
Interventions
DRUGEtoposide, carboplatin, melphalan, cisplatin, thiotepa
Sponsors
Gustave Roussy, Cancer Campus, Grand Paris
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 10 Years
Healthy volunteers
No
Inclusion criteria
* Medulloblastoma in patients less than 5 years of age * Brain PNET in patients less than 10 years of age * Histologically documented diagnosis * Body weight of \> 8 kg
Exclusion criteria
* Parents' refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age | — |
| Progression-free survival of children less than 10 years of age with brain PNET | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival of children less than 5 years of age with metastatic medulloblastoma | — |
| Toxicity | — |
| Long term sequelae | — |
Countries
France
Contacts
Primary ContactChantal Kalifa, MD
Backup ContactAgnès Laplanche, MD
Outcome results
None listed