Cancer, Leukemia, Stem Cell Transplantation
Conditions
Keywords
cancer, leukemia, stem cell transplant, complications
Brief summary
The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.
Interventions
BEHAVIORALC-Reactive Protein levels
Each patient enrolled in the study will have a serum quantitative c-reactive protein (crp) level drawn on the day of transplant, day 7 of transplant, and twice weekly after that until recovery of neutrophil count (approximately 20-25 days). Patients will be followed for 100 days post-transplant for the development of the following complications: 1. Sepsis- defined as fever, positive blood culture, need for fluid resuscitation and/or pressor support. 2. Acute GVHD \> grade II defined according to the Seattle criteria 3. VOD- defined according to the modified Seattle criteria
Sponsors
Ann & Robert H Lurie Children's Hospital of Chicago
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Months to 20 Years
Healthy volunteers
No
Inclusion criteria
* Age 6 months to 20 years * Patient undergoing a stem cell transplant (allogeneic, syngeneic, or autologous) at Childrens' Memorial Hospital * IRB approved informed consent (and assent for children age 12-17)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether quantitative c-reactive protein measurements can predict major morbidity and mortality in pediatric stem cell transplant patients. | To day +100 post transplant |
Countries
United States
Outcome results
None listed