Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors

Inclusion criteria

* Malignant Diseases: * Ewing's sarcoma/PNET: * CR1 - Metastatic disease at diagnosis, tumor volume \> 100 ml, pelvic bone primary * CR2 - Locally recurrent disease * Soft tissue sarcoma * CR1 - Metastatic disease at diagnosis or locally advanced disease where local control is suboptimal (i.e., inability to provide radiation therapy due to extent of disease). * CR2 - Locally recurrent disease (VGPR2 acceptable) * Hepatoblastoma: * VGPR1 - Patients with metastatic disease at diagnosis who have a persistently elevated alpha FP, or unresectable primary as a way of converting to resectable. * CR2/VGPR2 * Hodgkin's Disease: * VGPR1 - Progression on primary therapy/Refractory disease * CR2/VGPR2 * Germ Cell Tumor: * CR2/VGPR2 - recurrent disease * Wilms Tumor: * CR2/VGPR2 - recurrent disease * IRB approved signed written informed consent by patient and/or their legally authorized guardian. * Patients 21 years of age or younger at initial diagnosis, with older patients considered individually for primary pediatric disease diagnosis. * Adequate central venous access (double lumen CVL or 2 single lumen PCVC). * Adequate PBSC harvests with a minimum of 2.0 x 108 MNC/kg available for each PBSC rescue. * Organ Function: * Platelets \> 50,000/ml * SGOT \< 10 x upper limits of normal * Creatinine \< 1.5 x normal baseline * Normal cardiac function in accordance with institutional policies * Normal pulmonary function in accordance with institutional policies. * Physiologic status: * No active infections * Adequate performance status as measured by Karnofsky (\> 70%) or Lansky scale (\> 60%) as appropriate for age. * Bone Marrow Status * No evidence of morphologic involvement with tumor at the time of transplant Off Study Criteria: * Severe toxicity. Contact the Study Coordinator immediately and complete Adverse Reaction Form. * Disease progression or relapse prior to PBSC #1 or between PBSC rescue # 1 and #2. * Inability to collect adequate numbers of PBSC for successful transplantation. * Patient or parent/guardian refusal to remain on study.