End Stage Renal Disease
Conditions
Brief summary
To test the hypothesis that an exercise session combined with adequate nutritional supplementation improves skeletal muscle protein accretion during a hemodialysis session.
Interventions
2 oral ingestions per study visit of protein supplement containing a total of 960 kilocalories: 132.8 kilocalories from protein, 412.8 kilocalories from carbohydrates, and 412.8 kilocalories from fat; 6 study visits over a 12-month period
BEHAVIORALexercise
resistance training on a duel leg press consisting of 3 sets of 8-12 repetitions; the first 5 study visits over a 12-month period
Sponsors
Vanderbilt University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* On hemodialysis for more than 3 months, on a thrice weekly hemodialysis program. * Adequately dialyzed (Kt/V \> 1.2). * Age 18-75
Exclusion criteria
* Pregnant women. * Patients unable to perform exercise * Severe unstable underlying disease besides commonly associated with ESRD. Cardiac patients that are stable will be included. * Patients hospitalized within the last month prior to the study. * Patients with malfunctioning arterial-venous access (recirculation and/or blood flow \< 750 ml/min) * Patients receiving steroids and/or other immunosuppressive agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement in net protein muscle balance | 10 hours |
Secondary
| Measure | Time frame |
|---|---|
| improvement in net whole body protein balance | 10 hours |
Countries
United States
Outcome results
None listed