Acute Renal Failure
Conditions
Brief summary
We hypothesize that a nutritional supplementation with higher than standard protein content (2.0 gm/Kg/day vs 1.4 gm/Kg/day) will result in improved whole-body net protein balance when administered to critically ill patients with acute renal failure (ARF).
Interventions
DRUGTPN nutritional supplement
intravenous administration of nutritional supplement for 4 hours at a dosage of 30 kcal/kg/day, in the form of lipids, carbohydrates and protein; the non-protein calories are comprised of lipids (30%) and carbohydrates (70%)
Sponsors
Vanderbilt University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults ≥ 18 years of age admitted to the intensive care unit * New onset acute renal failure (ARF) or ARF superimposed on chronic kidney disease * ARF will be defined by a sustained (over 24 hours) increase in serum creatinine \> 0.5 mg/dl from baseline * Patients will be recruited for the study within 3-5 days following establishment of ARF
Exclusion criteria
* Institutionalized patient * Previous kidney transplant * Pregnancy * Unable to obtain consent from subject or legally recognized representative * ARF from urinary tract obstruction or a volume responsive pre-renal state. * Liver Failure * Recent cerebrovascular accident (CVA) * Coagulopathy defined as: Platelets \< 50, PT \> 20, INR \> 2.0 if the patient requires the placement of an arterial or venous catheter; if the patient does not require the placement of an arterial or venous catheter for the study, coagulopathy will not be a basis for exclusion. * Life expectancy \< 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| whole-body net protein balance | 10 hours |
Secondary
| Measure | Time frame |
|---|---|
| Net skeletal muscle protein balance | 10 hours |
Countries
United States
Outcome results
None listed