Ischemia
Conditions
Keywords
Blood supply, Mesentery
Brief summary
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify abnormalities without surgical intervention.
Detailed description
The electrical activity of the small intestine may contain important information that will help us diagnose gastrointestinal diseases. The major impediment to reducing mortality of mesenteric ischemia is the lack of a noninvasive diagnostic test that identifies the syndrome before extensive necrosis occurs. Mesenteric ischemia is caused by the lack of blood flow to the intestine. The Superconducting QUantum Interference Device (SQUID) measures the magnetic field of the intestinal smooth muscle. By comparing normal smooth muscle and that of patients with mesenteric ischemia, the investigators hope to identify abnormal disease states without surgery.
Interventions
None listed
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Vanderbilt University Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal subjects and those with diagnosed mesenteric ischemia
Exclusion criteria
* Subjects who report a tendency toward claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe a difference in the magnetic activity between the normal and diseased smooth muscle of the small intestine | 2010 |
Secondary
| Measure | Time frame |
|---|---|
| Create mathematical and computer models of electrical activity of smooth muscle | 2010 |
Countries
United States
Outcome results
None listed