Blood Coagulation Disorders, Inherited, Thrombotic Disorder
Conditions
Keywords
Hereditary Bleeding disorder, Thrombotic Disorder
Brief summary
The objective of this study will be to assess the coagulation system in-vitro in a variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin generation assay.
Detailed description
This is an exploratory study involving blood coagulation assays in a select group of individuals receiving treatment for their congenital or acquired bleeding or clotting disorder at UTHealth Houston. The ROTEG is a newly developed coagulation analyzer which allows the continuous assessment of whole blood coagulation from the formation of the first fibrin fibers and activated platelets, to the formation of a three-dimensional whole blood clot until the eventual dissolution of the clot. This device will not be used as a diagnostic or procedure tool. No recommendations regarding interpretation of the results or implications for future treatment will be provided.
Interventions
None listed
Sponsors
The University of Texas Health Science Center, Houston
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 98 Years
Healthy volunteers
No
Inclusion criteria
patients with congenital or acquired bleeding or clotting disorders who have provided informed consent and/or assent
Exclusion criteria
poor venous access
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess primary and secondary hemostasis in individuals with bleeding and clotting disorders | 24 hours | Coagulation will be assessed by continuously recording clot firmness, thrombin generation, and platelet function |
Countries
United States
Contacts
Primary ContactKatherine Addy, RN, BSN, MPH
Backup ContactDaisy Garcia, RN, BSN
Outcome results
None listed