Critical Illness, Shock, Trauma
Conditions
Keywords
Trauma, Critical Illness, Shock, Enteral Nutrition, Glutamine
Brief summary
Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.
Detailed description
In this prospective, randomized, controlled trial of patients with major torso trauma, high-dose enteral glutamine and enteral nutrition will be given to research subjects while controls will receive isocaloric, isonitrogenous enteral support. Enteral tolerance, bowel integrity and permeability will be evaluated. The systemic appearance of glutamine will be measured.
Interventions
DRUGGlutamine
Sponsors
National Institutes of Health (NIH)
The University of Texas Health Science Center, Houston
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult trauma patients meeting criteria for shock resuscitation * Major torso trauma * Admission to the Shock/Trauma Intensive Care Unit
Exclusion criteria
* Age \<18 years * Pregnant * Expected survival \< 24 hours * Bowel in discontinuity * Renal failure: baseline serum creatinine\>3.0 and/or dialysis * Admission total bilirubin \>10 mg/dl * History of cirrhosis or cirrhosis apparent on exploratory laparotomy * Asystole or CPR required
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut function | — |
Secondary
| Measure | Time frame |
|---|---|
| Systemic appearance of glutamine | — |
Countries
United States
Outcome results
None listed