Coronary Artery Disease, Coronary Stenosis
Conditions
Keywords
left main coronary artery, coronary artery disease
Brief summary
Recent technical advances in percutaneous coronary interventions have made it possible to approach patients with coronary lesions formerly considered to be classical candidates for bypass surgery, e.g. patients with left main coronary stenosis. However, it is still unclear whether the good long-term results achieved with the surgical therapy can be reproduced by an interventional strategy using drug-eluting stents (DES). The aim of the current trial is, therefore, to compare the clinical and angiographic results of PCI and CABG in patients with left main coronary stenosis.
Detailed description
Recent technical advances in percutaneous coronary interventions have made it possible to approach patients with coronary lesions formerly considered to be classical candidates for bypass surgery, e.g. patients with left main coronary stenosis. However, it is still unclear whether the good long-term results achieved with the surgical therapy can be reproduced by an interventional strategy using drug-eluting stents (DES). The aim of the current trial is, therefore, to compare the clinical and angiographic results of PCI and CABG in patients with left main coronary stenosis. The study was planned as a non-inferiority trial based on the hypothesis that PCI may be able to reach similar long-term results as compared to CABG.
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* Significant left main coronary stenosis \>= 50%
Exclusion criteria
* Acute myocardial infarction (STEMI \< 48h)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse coronary events (cardiac death, myocardial infarction, need for repeat revascularisation) | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional status (CCS-class) | — |
Countries
Germany