Coronary Artery Disease
Conditions
Keywords
exercise training, endothelial function
Brief summary
Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention. Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.
Detailed description
A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle. Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.
Interventions
BEHAVIORALExercise Training
Sponsors
University of Leipzig
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
ECT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* stable CAD * male gender
Exclusion criteria
* insulin-dependent diabetes mellitus * significant valvular heart disease * smoking * exercise-induced myocardial ischemia * conditions prohibiting exercise training
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial function | — |
Countries
Germany
Contacts
Primary ContactRainer P Hambrecht, MD
Backup ContactSandra Erbs, MD
Outcome results
None listed