Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

Change of EEG Activity and Cerebral Circulation During Induced Ventricular Fibrillation and Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in EP Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00176176

Enrollment

Registered

2005-09-15

Start date

Unknown

Completion date

Unknown

Last updated

2006-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventricular Fibrillation, Ventricular Tachycardia

Keywords

cerebral circulation

Brief summary

In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Detailed description

Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Interventions

DEVICEEEG

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Age \> 18 years * Positive agreement * EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia: * primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome * secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia

Exclusion criteria

* Severe neurological deficit * Cardiopulmonary resuscitation

Countries

Germany

Contacts

Primary ContactChristian Wolpert, PD, MD

christian.wolpert@med.ma. uni-heidelberg.de+49-621-383-2206

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026