Risk Indicators in Patients With Ventricular Fibrillation During Acute Myocardial Infarction

Indicators of Coagulation Activation and Inflammation Contributing to Ventricular Fibrillation Complicating Acute Myocardial Infarction

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00175942

Enrollment

300

Registered

2005-09-15

Start date

2003-02-28

Completion date

Unknown

Last updated

2005-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction, Sudden Cardiac Death

Keywords

acute myocardial infarction, ventricular fibrillation, coagulation, inflammation

Brief summary

Sudden cardiac death is in most cases triggered by ischemia-related ventricular tachyarrhythmias and accounts for 50% of deaths from cardiovascular disease in developed countries. Chronic elevation of indicators of coagulation activation has been found in patients with coronary heart disease , but a role of coagulation activation and proinflammatory state as a potential risk factor for ventricular fibrillation (VF) during acute myocardial infarction has not been investigated.

Detailed description

Sudden cardiac death (SCD) is in most cases triggered by ischemia-related ventricular arrhythmias and is responsible for 50% of the mortality from cardiovascular disease in developed countries (1). Chronic elevation of indicators of coagulation activation and inflammation has been found in patients with coronary heart disease and may contribute to vasculatory disorders probably contributing to the development of arrhythmogenesis. However, the role of coagulation activation as a potential risk factor for ventricular fibrillation during acute myocardial infarction has not been investigated yet.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

0 Years to No maximum

Healthy volunteers

Inclusion criteria

ST-elevation myocardial infarction ventricular fibrillation during acute MI

Exclusion criteria

NSTEMI coagulation disorders, e.g.intake of coumadin

Countries

Germany

Contacts

Primary ContactElif Elmas, MD, Dr.

00496213833988

Backup ContactMartina Brückmann, MD, Dr.

Outcome results