Feasibility Study: The Effect of Prazosin for Nighttime Symptoms of Civilian PTSD

The Effect of Prazosin for Nighttime Symptoms of Civilian PTSD

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00174551

Enrollment

Registered

2005-09-15

Start date

2003-11-30

Completion date

2005-11-30

Last updated

2006-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress Disorders, Post-Traumatic

Brief summary

Investigating the effect of prazosin for nighttime symptoms of civilian Posttraumatic Stress Disorder.

Detailed description

Each subject will receive prazosin and placebo trials, the order randomized. Day and nighttime symptoms will be monitored.

Interventions

DRUGprazosin

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* must meet DSM-IV criterion for PTSD

Exclusion criteria

* Must not have untreated sleep apnea

Design outcomes

Primary

Measure	Time frame
Sleep time	—
REM sleep time	—
Nightmare frequency	—
CGI	—

Secondary

Measure	Time frame
Distressed Awakenings frequency	—
PCL-C	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026