Heart Transplantation
Conditions
Keywords
1. Transplant vasculopathy, 2. Endothelial dysfunction, 3. Myocardial perfusion imaging, 4. Intravascular vascular ultrasound
Brief summary
Progressive cardiac allograft vasculopathy (CAV) is a serious complication in long-term survivors after heart transplantation. Therefore, we hypothesize that CAV is a diffuse and progressive process, and endothelial function may play an important role in predicting clinical outcome after heart transplantation. Therefore, this single-blinded study is designed to evaluate endothelial function, microvascular flow response and morphology of coronary artery in cardiac allografts, 1. The simultaneous use of IVUS and Doppler wire instrumentation in different pharmacological stress; 2. Tl-201 SPECT (dipyridamole stress/rest); to evaluate the correlation of endothelial function, coronary morphology change and Tl-201 dipyridamole stress myocardial perfusion image.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
DEFINED_POPULATION
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1\. Heart transplant receipients who undergoing the coronary angiographic follow-up as standard protocols.
Exclusion criteria
1. Acute illness conditions including infection, congestive heart failure (NYHA Fc III, IV), etc. 2. Coronary angiographic finding: coronary stenosis\>30% (as grade III, IV by Klauss V et al, Am J Cardiol 1995; 76:463-6). 3. Creatinine \>3.0 mg/dl
Countries
Taiwan
Contacts
Primary ContactChii-Ming Lee, MD, phD
Outcome results
None listed