Hypertension
Conditions
Keywords
hypertension, high blood pressure, valsartan, hydrochlorothiazide
Brief summary
This study will test the effectiveness and safety of a combination treatment in patients whose blood pressure is not controlled with a single medication.
Interventions
Sponsors
Novartis
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* Patients with mild to moderate hypertension
Exclusion criteria
* Severe hypertension * History of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm * Liver, kidney, or pancreas disease * Insulin dependent diabetes * Allergy to certain medications used to treat high blood pressure Other protocol-defined
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in diastolic blood pressure from baseline after 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in systolic blood pressure from baseline after 8 weeks | — |
| Change from baseline in standing systolic and diastolic blood pressure after 8 weeks | — |
| Diastolic blood pressure less than 90 mmHg or at least a 10 mmHg decrease in diastolic pressure after 8 weeks | — |
| Diastolic blood pressure less than 90 mmHg after 8 weeks | — |
| Adverse events and serious adverse events at 8 weeks | — |
Countries
Germany, Switzerland
Outcome results
None listed